Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases

Baillie, G. S. (2009) Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases. FEBS Journal, 276(7), pp. 1790-1799. (doi:10.1111/j.1742-4658.2009.06926.x)

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Publisher's URL: http://dx.doi.org/10.1111/j.1742-4658.2009.06926.x

Abstract

cAMP is the original second messenger that is synthesized in response to a number of extracellular stimuli. Recent advances in cAMP reporter technology have given an insight into how cAMP signals retain their specificity. Spatial and temporal cAMP dynamics are regulated by discretely positioned phosphodiesterases that act as sinks to create simultaneous, multiple cAMP gradients in many cellular locations. Such gradients are sampled within microdomains that contain anchored cAMP effector proteins. Compartmentalization of proteins that produce, degrade and are activated by cAMP is crucial for the specificity of action required for normal cell function

Item Type:Articles
Keywords:cAMP • compartmentalization • compartmentalized signalling • EPAC • FRET • G-protein coupled receptor • PDE • PDE4 • PKA
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Baillie, Professor George
Authors: Baillie, G. S.
Subjects:Q Science > QH Natural history > QH345 Biochemistry
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:FEBS Journal
Publisher:Wiley-Blackwell Publishing Ltd.
ISSN:1742-464X
ISSN (Online):1742-4658
Published Online:23 February 2009
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
438301Phosphodiesterase-4 isoforms - intracellular targeting, regulation and potential therapeutic targetsMiles HouslayMedical Research Council (MRC)G0600765Institute of Neuroscience and Psychology