Baillie, G. S. (2009) Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases. FEBS Journal, 276(7), pp. 1790-1799. (doi: 10.1111/j.1742-4658.2009.06926.x)
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Publisher's URL: http://dx.doi.org/10.1111/j.1742-4658.2009.06926.x
Abstract
cAMP is the original second messenger that is synthesized in response to a number of extracellular stimuli. Recent advances in cAMP reporter technology have given an insight into how cAMP signals retain their specificity. Spatial and temporal cAMP dynamics are regulated by discretely positioned phosphodiesterases that act as sinks to create simultaneous, multiple cAMP gradients in many cellular locations. Such gradients are sampled within microdomains that contain anchored cAMP effector proteins. Compartmentalization of proteins that produce, degrade and are activated by cAMP is crucial for the specificity of action required for normal cell function
| Item Type: | Articles |
|---|---|
| Keywords: | cAMP • compartmentalization • compartmentalized signalling • EPAC • FRET • G-protein coupled receptor • PDE • PDE4 • PKA |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Baillie, Professor George |
| Authors: | Baillie, G. S. |
| Subjects: | Q Science > QH Natural history > QH345 Biochemistry |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
| Journal Name: | FEBS Journal |
| Publisher: | Wiley-Blackwell Publishing Ltd. |
| ISSN: | 1742-464X |
| ISSN (Online): | 1742-4658 |
| Published Online: | 23 February 2009 |
| Related URLs: |
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