Prognostic utility of a gene-expression signature in untreated node-negative breast cancer

Schmidt, M., Bohm, D., Glawatz, C., Victor, A., Gehrmann, M., Messow, C. , Steiner, E., Munnes, M., Lehr, H.A. and Kolbl, H. (2005) Prognostic utility of a gene-expression signature in untreated node-negative breast cancer. Zentralblatt für Gynäkologie(4), p. 127.

Abstract

<b>Purpose:</b> Gene expression profiling has the potential to lead to a more accurate prognostic classification of breast cancer patients. Recently, a set of 70 genes had been identified that allowed risk classification of node-negative patients. We analysed the prognostic utility of a subset of these genes and compared it with established prognostic factors in a collective of 150 untreated node-negative breast cancer patients. <b>Methods:</b> cRNA of 150 untreated node-negative breast cancer patients was hybridized on the Affymetrix HG-U133A array and probe sets corresponding to the set of 70 genes were identified. A good and poor prognosis profile was generated for the expression of 52 genes. The prognostic utility of this gene-expression signature was then compared with established prognostic factors (i.e. histological grade, tumor size and steroid hormone receptor status). The prognostic utility for disease-free survival (DFS) was evaluated using univariate and multivariate statistical analyses. <b>Results:</b> 33 (22%) of the tumors were assigned to the good and 117 (78%) to the poor prognosis group based on the gene-expression signature. This led to a sensitivity of 93% with a specificity of 26%. 5-year DFS was 94% in the good and 78% in the poor prognosis group, respectively. However, this difference diminished with longer follow-up (p=0.167). Of the prognostic factors analysed, only histological grade was associated with DFS (p<0,0005). <b>Conclusion:</b> histological grade had a higher prognostic utility than the gene-expression signature in our cohort of untreated node-negative breast cancer patients

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Messow, Dr Martina
• Authors: Schmidt, M., Bohm, D., Glawatz, C., Victor, A., Gehrmann, M., Messow, C., Steiner, E., Munnes, M., Lehr, H.A., and Kolbl, H.
• Subjects: R Medicine > R Medicine (General)
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre
• Journal Name: Zentralblatt für Gynäkologie
• Publisher: Johann Ambrosius Barth Verlag in Medizinverlage Heidelberg GmbH & Co. KG
• ISSN: 0044-4197
• ISSN (Online): 1438-9762
• Published Online: 01 January 2005