Prognostic value of tissue inhibitor of metalloproteinase-1 for cardiovascular death among patients with cardiovascular disease: results from the AtheroGene study

Lubos, E., Schnabel, R., Rupprecht, H.J., Bickel, C., Messow, C. , Prigge, S., Cambien, F., Tiret, L., Munzel, T. and Blankenberg, S. (2006) Prognostic value of tissue inhibitor of metalloproteinase-1 for cardiovascular death among patients with cardiovascular disease: results from the AtheroGene study. European Heart Journal, 27(2), pp. 150-156. (doi: 10.1093/eurheartj/ehi582)

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Abstract

<p><b>Aims</b> Metalloproteinases are proteolytic enzymes, which decompose the extracellular matrix, influence cardiac remodelling, and are inhibited by tissue inhibitor of metalloproteinases (TIMPs). Little is known about the prognostic impact of the TIMP-1/matrix metalloproteinase complex in patients with future cardiovascular death.</p> <p><b>Methods and results</b> In 1979 patients with suspected coronary artery disease (CAD), TIMP-1 has been determined at baseline. Among 1945 (98.4%) patients with a mean follow-up period of 2.6±1.2 years, 75 patients died because of cardiovascular causes.</p> <p>Mean concentrations of TIMP-1 were higher among patients who experienced a fatal cardiovascular event than among those who did not (820 vs. 692 ng/mL; P <0.001). Age and sex adjusted hazard ratio of future cardiovascular death associated with one standard deviation of TIMP-1 level, was 1.37 (95% CI: 1.17–1.61; P<0.001). The hazard ratio remained nearly identical after adjustment for clinical and therapeutic confounders. B-type natriuretic peptide (2.75, 95% CI: 1.94–3.89; P<0.001), C-reactive protein (1.79, 95% CI: 1.43–2.24; P<0.001), and TIMP-1 (1.30, 95% CI: 1.07–1.58; P=0.008) were independently associated with future cardiovascular death.</p> <p><b>Conclusion</b> In patients with CAD, TIMP-1 proves as an independent predictor for future cardiovascular death.</p>

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Messow, Dr Martina
Authors: Lubos, E., Schnabel, R., Rupprecht, H.J., Bickel, C., Messow, C., Prigge, S., Cambien, F., Tiret, L., Munzel, T., and Blankenberg, S.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre
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Journal Name:European Heart Journal
Journal Abbr.:Eur. heart j.
Publisher:Oxford University Press
ISSN:0195-668X
ISSN (Online):1522-9645
Published Online:17 October 2005

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