Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence blocking compounds

Wang, D. et al. (2011) Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence blocking compounds. Journal of Biological Chemistry, 286(34), pp. 29922-29931. (doi:10.1074/jbc.M111.233858)

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Abstract

A class of anti-virulence compounds, the salicylidene acylhydrazides, have been widely reported to block the function of the type three secretion system of several Gram-negative pathogens by a previously unknown mechanism. In this work, we provide the first identification of bacterial proteins that are targeted by this group of compounds. We provide evidence that their mode of action is likely to result from a synergistic effect arising from a perturbation of the function of several conserved proteins. We also examine the contribution of selected target proteins to the pathogenicity of Yersina pseudotuberculosis and to expression of virulence genes in Escherichia coli O157.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Wang, Mr Dai and Gabrielsen, Dr Mads and Roe, Dr Andrew and Burchmore, Dr Richard and Herzyk, Dr Pawel and Smith, Dr Brian and Byron, Professor Olwyn and Mitchell, Professor Timothy
Authors: Wang, D., Zetterstrom, C.E., Gabrielsen, M., Beckham, K.S.H., Tree, J.J., Macdonald, S.E., Byron, O., Mitchell, T.J., Gally, D.L., Herzyk, P., Mahajan, A., Uvell, H., Burchmore, R., Smith, B.O., Elofsson, M., and Roe, A.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Journal of Biological Chemistry
Journal Abbr.:J Biol Chem.
Publisher:American Society for Biochemistry and Molecular Biology, Inc.
ISSN:0021-9258
ISSN (Online):1083-351X
Published Online:01 July 2011
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
491441A biochemical and molecular analysis of the YhaO membrane protein in Escherichia coli O157:H7Andrew RoeBiotechnology and Biological Sciences Research Council (BBSRC)BB/G011389/1Infection Immunity and Inflammation Life Sciences