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A multi-component fiber-reinforced PHEMA-based hydrogel/HAPEX™ device for customized intervertebral disc prosthesis

Gloria, A., De Santis, R., Ambrosio, L., Causa, F. and Tanner, K.E. (2011) A multi-component fiber-reinforced PHEMA-based hydrogel/HAPEX™ device for customized intervertebral disc prosthesis. Journal of Biomaterials Applications, 25(8), pp. 795-810. (doi: 10.1177/0885328209360933)

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Abstract

Spinal disease due to intervertebral disc degeneration represents a serious medical problem which affects many people worldwide. Disc arthroplasty may be considered the future ‘‘gold standard’’ of back pain treatment, even if problems related to available disc prostheses are considered. Hence, the aim of the present study was to improve the artificial disc technology by proposing the engineering of a pilot-scale device production process for a total multi-component intervertebral disc prosthesis. The device is made up of a poly(2-hydroxyethyl methacrylate)/poly(methyl methacrylate) (PHEMA/PMMA) (80/20 w/w) semi interpenetrating polymer network (s-IPN) composite hydrogel reinforced with poly(ethylene terephthalate) (PET) fibers as annulus/nucleus substitute, and two hydroxyapatite-reinforced polyethylene composite (HAPEXTM) endplates in order to anchor the multi-component device to the vertebral bodies. Static and dynamic–mechanical characterization show appropriate mechanical behavior. An example of engineering of a suitable pilot-scale device production process is also proposed in order to manufacture custom made implants.

Item Type:	Articles
Keywords:	Intervertebral disc, reverse engineering, technologies, fiberreinforced hydrogel, customized prosthesis, multi-component model, mechanical testing
Status:	Published
Refereed:	Yes
Glasgow Author(s) Enlighten ID:	Tanner, Professor Kathleen
Authors:	Gloria, A., De Santis, R., Ambrosio, L., Causa, F., and Tanner, K.E.
College/School:	College of Science and Engineering > School of Engineering > Biomedical Engineering
Research Group:	Biomaterials
Journal Name:	Journal of Biomaterials Applications
Publisher:	Sage Publications Ltd.
ISSN:	0885-3282
ISSN (Online):	1530-8022
Published Online:	28 May 2010

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References

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Deposit and Record Details

ID Code:	54077
Depositing User:	Professor Kathleen Tanner
Datestamp:	20 Jul 2011 14:55
Last Modified:	22 Sep 2021 17:57
Date of first online publication:	28 May 2010