Glycan structure of a high mannose glycoprotein from raman optical activity

Johannessen, C., Pendrill, R., Widmalm, G., Hecht, L. and Barron, L. D. (2011) Glycan structure of a high mannose glycoprotein from raman optical activity. Angewandte Chemie (International Edition), 50(23), pp. 5349-5341. (doi: 10.1002/anie.201008258) (PMID:21523866)

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Abstract

<b>A revealing signature:</b> The glycan structure of intact yeast external invertase, a high-mannose glycoprotein used as biocatalyst, was investigated by using Raman optical activity (ROA) spectroscopy. The conformational preferences present in mannose-containing di- and trisaccharides were found to be preserved in the glycan chains, with secondary polpeptide backbone structure suppressed.

Item Type:Articles
Keywords:Glycoproteins, glycosylation, invertase, Raman optical activity
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hecht, Dr Lutz and Barron, Professor Laurence and Johannessen, Dr Christian
Authors: Johannessen, C., Pendrill, R., Widmalm, G., Hecht, L., and Barron, L. D.
Subjects:Q Science > QD Chemistry
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Angewandte Chemie (International Edition)
Publisher:Wiley - V C H Verlag GmbH & Co. KGaA
ISSN:1433-7851
ISSN (Online):1521-3757
Published Online:26 April 2011

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