Modeling Cell Movement and Chemotaxis Using Pseudopod-Based Feedback

Neilson, M.P., Mackenzie, J.A., Webb, S.D. and Insall, R.H. (2011) Modeling Cell Movement and Chemotaxis Using Pseudopod-Based Feedback. SIAM Journal on Scientific Computing, 33(3), pp. 1035-1057. (doi: 10.1137/100788938)

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A computational framework is presented for the simulation of eukaryotic cell migration and chemotaxis. An empirical pattern formation model, based on a system of nonlinear reaction-diffusion equations, is approximated on an evolving cell boundary using an arbitrary Lagrangian Eulerian surface finite element method (ALE-SFEM). The solution state is used to drive a mechanical model of the protrusive and retractive forces exerted on the cell boundary. Movement of the cell is achieved using a level set method. Results are presented for cell migration with and without chemotaxis. The simulated behavior is compared with experimental results of migrating Dictyostelium discoideum cells

Item Type:Articles
Glasgow Author(s) Enlighten ID:Neilson, Dr Matthew and Insall, Professor Robert
Authors: Neilson, M.P., Mackenzie, J.A., Webb, S.D., and Insall, R.H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:SIAM Journal on Scientific Computing
Publisher:Society for Industrial and Applied Mathematics
ISSN (Online):1095-7197
Published Online:05 May 2011

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
506871Computational modelling of cell movement and chemotaxisRobert InsallMedical Research Council (MRC)G0802579Beatson Institute for Cancer Research