Fgfr3 regulates development of the caudal telencephalon

Moldrich, R.X. et al. (2011) Fgfr3 regulates development of the caudal telencephalon. Developmental Dynamics, 240(6), pp. 1586-1599. (doi: 10.1002/dvdy.22636) (PMID:21491541)

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Abstract

The fibroblast growth factor receptor 3 (Fgfr3) is expressed in a rostral(low) to caudal(high) gradient in the developing cerebral cortex. Therefore, we hypothesized that Fgfr3 contributes to the correct morphology and connectivity of the caudal cortex. Overall, the forebrain structures appeared normal in Fgfr3(-/-) mice. However, cortical and hippocampal volumes were reduced by 26.7% and 16.3%, respectively. Hypoplasia was particularly evident in the caudo-ventral region of the telencephalon where proliferation was mildly decreased at embryonic day 18.5. Dysplasia of GABAergic neurons in the amygdala and piriform cortex was seen following GAD67 immunohistochemistry. Dye-tracing studies and diffusion magnetic resonance imaging and tractography detected a subtle thalamocortical tract deficit, and significant decreases in the stria terminalis and lateral arms of the anterior commissure. These results indicate the subtle role of Fgfr3 in formation of caudal regions of the telencephalon affecting some brain projections. Developmental Dynamics 240:1586-1599, 2011. (C) 2011 Wiley-Liss, Inc

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Iwata, Dr Tomoko and Dewar, Dr Deborah and Holmes, Dr William and Rankin, Dr Alastair
Authors: Moldrich, R.X., Mezzera, C., Holmes, W.M., Goda, S., Brookfield, S.J., Rankin, A.J., Barr, E., Kurniawan, N., Dewar, D., Richards, L.J., López-Bendito, G., and Iwata, T.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Developmental Dynamics
Publisher:Wiley
ISSN:1058-8388
ISSN (Online):1097-0177
Published Online:12 April 2011

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