Tardive dyskinesia and deficit schizophrenia

Telfer, S., Somashekar, S., Krishnadas, R. , McCreadie, R. and Kirkpatrick, B. (2011) Tardive dyskinesia and deficit schizophrenia. Acta Psychiatrica Scandinavica, 124(5), pp. 357-362. (doi: 10.1111/j.1600-0447.2011.01751.x)

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Abstract

<p>Objective: Despite comparable antipsychotic exposure, some patients experience involuntary movements yet others do not. Negative symptoms have been associated with tardive dyskinesia, but it is not certain if this is an association with primary negative symptoms or the effects of medications. The aim of the present study was to determine whether patients with deficit schizophrenia (who have primary negative symptoms) are more likely to experience tardive dyskinesia than those with nondeficit schizophrenia.</p> <p>Method: In 2006 all the people with a clinical diagnosis of schizophrenia in Nithsdale, South West Scotland, were identified using the ‘key informant’ method. These patients were categorized into those with and without the deficit syndrome, and assessed for the presence of tardive dyskinesia (TD). Patients were also assessed for akathisia and extrapyramidal side effects.</p> <p>Results: Of the 131 people assessed, 31 were categorised as having deficit schizophrenia (23.7%) and 100 people (76.3%) as nondeficit. There were no difference between the two groups with regards to age, antipsychotic exposure and duration of illness. There was a significant association between deficit features and TD with an odds ratio = 2.97 [95% CI 1.128-6.88, p=0.009].</p> <p>Conclusion: Our findings support the proposal that the pathological process underlying deficit schizophrenia can predispose to the development of tardive dyskinesia.</p>

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Krishnadas, Dr Rajeev and McCreadie, Prof Robin
Authors: Telfer, S., Somashekar, S., Krishnadas, R., McCreadie, R., and Kirkpatrick, B.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing
Journal Name:Acta Psychiatrica Scandinavica
ISSN:0001-690X
ISSN (Online):1600-0447

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