A cluster randomised controlled trial of pharmacist led Statin Outreach Support (SOS) in primary care: design and baseline characteristics

Lowrie, R., Morrison, J. and McConnachie, A. (2010) A cluster randomised controlled trial of pharmacist led Statin Outreach Support (SOS) in primary care: design and baseline characteristics. Contemporary Clinical Trials, 31(4), pp. 303-311. (doi: 10.1016/j.cct.2010.03.010)

Full text not currently available from Enlighten.

Abstract

<p>Background: Statins reduce the risk of vascular events, however statin prescribing is often sub optimal and better evidence is needed to inform quality improvements. The Statin Outreach Support (SOS) trial was designed to test the efficacy of pharmacist led educational outreach directed at General Practices, aiming to improve statin prescribing for community dwelling patients with vascular disease. This paper describes the study rationale, design, methods and baseline characteristics of participants.</p> <p>Design: The SOS trial was designed to investigate whether practices receiving SOS improve their statin prescribing and patients achieve reduced cholesterol levels. It was a prospective, single blind, cluster randomised controlled trial with a follow-up period of 5 months minimum post SOS intervention delivery.</p> <p>Results: Thirty one practices were recruited from the UK's largest Health Board area. At randomisation, 16 practices were allocated to SOS and 15 to usual care with 4040 patients included at baseline. Participating practices showed few differences compared with non-participating practices; practices and patients randomised to each arm of the study had similar distributions with respect to age, complications, cholesterol levels and statin prescribing. Baseline data compared favourably with landmark, placebo-controlled statin trials.</p> <p>Conclusions: Compared with existing implementation research, SOS trial has more participants, a detailed description of baseline characteristics and over 90% power (at 5% significance) to detect a difference of 12% in the proportion of patients with controlled cholesterol after SOS.</p>

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Morrison, Professor Jill and McConnachie, Professor Alex and Lowrie, Dr Richard
Authors: Lowrie, R., Morrison, J., and McConnachie, A.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > General Practice and Primary Care
College of Social Sciences > School of Social and Political Sciences > Sociology Anthropology and Applied Social Sciences
Journal Name:Contemporary Clinical Trials
ISSN:1551-7144
ISSN (Online):1559-2030
Published Online:27 March 2010

University Staff: Request a correction | Enlighten Editors: Update this record