Age-related normograms of serum antimüllerian hormone levels in a population of infertile women: a multicenter study

Almog, B. et al. (2011) Age-related normograms of serum antimüllerian hormone levels in a population of infertile women: a multicenter study. Fertility and Sterility, 95(7), pp. 2359-2363. (doi:10.1016/j.fertnstert.2011.02.057)

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Publisher's URL: http://dx.doi.org/10.1016/j.fertnstert.2011.02.057

Abstract

Objective: To produce age-related normograms for serum antimullerian hormone (AMH) level in infertile women without polycystic ovaries (non-PCO). Design: Retrospective cohort analysis. Setting: Fifteen academic reproductive centers. Patient(s): A total of 3,871 infertile women. Intervention(s): Blood sampling for AMH level. Main Outcome Measure(s): Serum AMH levels and correlation between age and different percentiles of AMH. Result(s): Age-related normograms for the 3rd, 10th, 25th, 50th, 75th, 90th, and 97th percentiles of AMH were produced. We found that the curves of AMH by age for the 3rd to 50th percentiles fit the model and appearance of linear relation, whereas the curves of >75th percentiles fit cubic relation. There were significant differences in AMH and FSH levels and in antral follicle count (AFC) among women aged 24-33 years, 34-38 years, and >= 39 years. Multivariate stepwise linear regression analysis of FSH, age, AFC, and the type of AMH kit as predictors of AMH level shows that all variables are independently associated with AMH level, in the following order: AFC, FSH, type of AMH kit, and age. Conclusion(s): Age-related normograms in non-PCO infertile women for the 3rd to 97th percentiles were produced. These normograms could provide a reference guide for the clinician to consult women with infertility. However, future validation with longitudinal data is still needed. (Fertil Steril (R) 2011; 95: 2359-63. (C) 2011 by American Society for Reproductive Me

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Nelson, Professor Scott
Authors: Almog, B., Shehata, F., Suissa, S., Holzer, H., Shalom-Paz, E., La Marca, A., Muttukrishna, S., Blazar, A., Hackett, R., Nelson, S.M., Cunha-Filho, J.S., Eldar-Geva, T., Margalioth, E.J., Raine-Fenning, N., Jayaprakasan, K., McIlveen, M., Wunder, D., Freour, T., Nardo, L.G., Balasch, J., Peñarrubia, J., Smeenk, J., Gnoth, C., Godehardt, E., Lee, T.-H., Lee, M.-S., Levin, I., Gamzu, R., and Tulandi, T.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Fertility and Sterility
ISSN:0015-0282

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