Enlighten
Research publications by members of the University of Glasgow
home > services > Enlighten

A comparison of epidural infusions of fentanyl or pethidine with bupivacaine in the management of postoperative pain

Cox, C.R., Serpell, M.G., Bannister, J., Coventry, D.M., and Williams, D.R. (1996) A comparison of epidural infusions of fentanyl or pethidine with bupivacaine in the management of postoperative pain. Anaesthesia, 51 (7). pp. 695-698. ISSN 0003-2409

Full text not currently available from Enlighten.

Publisher's URL: 10.1111/j.1365-2044.1996.tb07859.x

Abstract

A double-blind randomised clinical trial was undertaken in 40 patients undergoing major abdominal surgery. Postoperative pain relief was provided using epidural infusions of 0.06% bupivacaine with fentanyl 4 μg.ml-1 (n = 20) (group F) or with pethidine 1.5 mg.ml-1 (n = 20) (group P). Postoperative pain scores using a visual analogue scale (0-100 mm) were not significantly different between the two groups. Median pain scores were 0-19 mm at all times of assessment indicating that good analgesia was provided by both regimens. There was no significant difference between the epidural infusion rates in the two groups. The side effects and effect on pulmonary function were similar in each group. Nine patients were withdrawn from the study (four from group F, five from group P) due to failure of the epidural technique or other complications. Fourteen patients, equally distributed, required a total of 24 epidural 'top-ups' by an anaesthetist because of inadequate analgesia. We demonstrated no advantage with epidural pethidine over fentanyl when used by infusion in combination with bupivacaine in the management of postoperative pain.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s):Serpell, Dr Michael
Authors: Cox, C.R., Serpell, M.G., Bannister, J., Coventry, D.M., and Williams, D.R.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine
Journal Name:Anaesthesia
Publisher:Wiley-Blackwell Publishing Ltd.
ISSN:0003-2409
ISSN (Online):1365-2044
Published Online:22 February 2007

University Staff: Request a correction | Enlighten Editors: Update this record