Mitochondrial complex I: A central regulator of the aging process

Stefanatos, R. and Sanz, A. (2011) Mitochondrial complex I: A central regulator of the aging process. Cell Cycle, 10(10), pp. 1528-1532. (doi: 10.4161/cc.10.10.15496)

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Mitochondria are considered major regulators of longevity, although their exact role in aging is not fully understood. Data from different laboratories show a negative correlation between reactive oxygen species (ROS) generated by complex I and lifespan. This suggests that complex I has a central role in the regulation of longevity. Here, we review data that both support and refute the role of complex I as a pacemaker of aging. We include data from our laboratory, where we have manipulated ROS production by the electron transport chain (ETC) in Drosophila melanogaster. The by-pass of complex I increases the lifespan of the fruit fly, but it is not clear if this is caused by a reduction in ROS or by a change in the NAD(+) to NADH ratio. We propose that complex I regulates aging through at least two mechanisms: (1) an ROS-dependent mechanism that leads to mitochondrial DNA damage and (2) an ROS-independent mechanism through the control of the NAD(+) to NADH ratio. Control of the relative levels of NAD(+) and NADH would allow the regulation of (1) glyco-and (2) lipoxidative-damage and (3) the activation of sirtuins

Item Type:Articles
Glasgow Author(s) Enlighten ID:Stefanatos, Miss Rhoda and Sanz Montero, Professor Alberto
Authors: Stefanatos, R., and Sanz, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Cell Cycle

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