The culture of olfactory ensheathing cells (OECs)—a distinct glial cell type

Higginson, J.R. and Barnett, S.C. (2011) The culture of olfactory ensheathing cells (OECs)—a distinct glial cell type. Experimental Neurology, 229(1), pp. 2-9. (doi: 10.1016/j.expneurol.2010.08.020)

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Olfactory ensheathing cells (OECs) have become a popular candidate for the transplant-mediated repair of the damaged CNS. In this review a description is made of the origins of these cells and a historical development of their purification and maintenance in culture. In addition, we illustrate the cellular and molecular characteristics of OECs and emphasise that although they share many properties with Schwann cells, they possess several inherent differences which may allow them to be more beneficial for CNS repair. In summary, OECs are distinct glial cells and the detailed understanding of their biological and molecular properties is essential in ensuring their clinical efficacy after cell transplantation. This article is part of a Special Issue entitled: Understanding olfactory ensheathing glia and their prospect for nervous system repair. (C) 2010 Elsevier Inc. All rights reserved

Item Type:Articles
Glasgow Author(s) Enlighten ID:Higginson, Dr Jennifer and Barnett, Professor Susan
Authors: Higginson, J.R., and Barnett, S.C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Experimental Neurology

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