Hueber, A. J., Alves-Filho, J. C., Asquith, D. L., Michels, C., Millar, N. L. , Reilly, J. H., Graham, G. J. , Liew, F. Y., Miller, A. M. and McInnes, I. B. (2011) IL-33 induces skin inflammation with mast cell and neutrophil activation. European Journal of Immunology, 41(8), pp. 2229-2237. (doi: 10.1002/eji.201041360) (PMID:21674479)
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Publisher's URL: http://dx.doi.org/10.1002/eji.201041360
Abstract
Abstract Psoriasis is a common chronic autoimmune condition of the skin characterized by hyperplasia of epidermal keratinocytes associated with pro-inflammatory cytokines. IL-33 is a new member of the IL-1 superfamily that signals through the ST2 receptor and was originally defined as an inducer of T helper 2 (Th2) cytokines. Recently, broader immune activatory potential has been defined for IL-33 particularly via mast cell activation and neutrophil migration. Here we show that ST2-/- mice exhibited reduced cutaneous inflammatory responses compared to WT mice in a phorbol ester-induced model of skin inflammation. Furthermore, injections of IL-33 into the ears of mice induced an inflammatory skin lesion. This inflammatory response was partially dependent on mast cells as mast cell deficient mice (Kit<sup>W-sh/W-sh</sup>) showed delayed responses to IL-33. IL-33 also recruited neutrophils to the ear, an effect mediated in part by increased production of the chemokine KC (CXCL1). Finally, we show that IL-33 expression is up-regulated in the epidermis of clinical psoriatic lesions, compared to healthy skin. These results therefore demonstrate that IL-33 may play a role in psoriasis-like plaque inflammation. IL-33 targeting may provide a new treatment strategy for psoriasis
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | McInnes, Professor Iain and Liew, Prof Foo and Reilly, Mr James and Asquith, Dr Darren and Miller, Dr Ashley and Millar, Professor Neal and Alves-Filho, Dr Jose and Michels, Dr Chesney and Hueber, Dr Axel and Graham, Professor Gerard |
| Authors: | Hueber, A. J., Alves-Filho, J. C., Asquith, D. L., Michels, C., Millar, N. L., Reilly, J. H., Graham, G. J., Liew, F. Y., Miller, A. M., and McInnes, I. B. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | European Journal of Immunology |
| Publisher: | Wiley-VCH Verlag |
| ISSN: | 0014-2980 |
| ISSN (Online): | 1521-4141 |
| Published Online: | 24 June 2011 |
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