Rationale, design and population baseline characteristics of the PERFORM Vascular Project: an ancillary study of the Prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history oF ischemic stroke or transient ischemic attack (PERFORM) trial

Hennerici, M.G., Bots, M.L., Ford, I. , Laurent, S. and Touboul, P.J. (2010) Rationale, design and population baseline characteristics of the PERFORM Vascular Project: an ancillary study of the Prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history oF ischemic stroke or transient ischemic attack (PERFORM) trial. Cardiovascular Drugs and Therapy, 24(2), pp. 175-180. (doi: 10.1007/s10557-010-6231-2)

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Publisher's URL: http://dx.doi.org/10.1007/s10557-010-6231-2

Abstract

<p><b>Purpose</b></p> <p>PERFORM is exploring the efficacy of terutroban versus aspirin for secondary prevention in patients with a history of ischemic stroke or transient ischemic attacks (TIAs). The PERFORM Vascular Project will evaluate the effect of terutroban on progression of atherosclerosis, as assessed by change in carotid intima-media thickness (CIMT) in a subgroup of patients.</p> <p><b>Methods and results</b></p> <p>The Vascular Project includes structural (CIMT, carotid plaques) and functional (carotid stiffness) vascular studies in all patients showing at least one carotid plaque at entry. Expected mean follow-up is 36 months. Primary endpoint is rate of change of CIMT. Secondary endpoints include emergent plaques and assessment of carotid stiffness. 1,100 patients are required for 90% statistical power to detect treatment-related CIMT difference of 0.025 mm. The first patient was randomized in April 2006.</p> <p><b>Conclusions</b></p> <p>The PERFORM Vascular Project will investigate terutroban’s effect on vascular structure and function in patients with a history of ischemic stroke or TIAs.</p>

Item Type:Articles (Editorial)
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ford, Professor Ian
Authors: Hennerici, M.G., Bots, M.L., Ford, I., Laurent, S., and Touboul, P.J.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre
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Journal Name:Cardiovascular Drugs and Therapy
Journal Abbr.:Cardiovasc Drugs Ther
Publisher:Springer
ISSN:0920-3206
ISSN (Online):1573-7241
Published Online:20 May 2010

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