Li, Y. et al. (2011) Genetic variants in the KIF6 region and coronary event reduction from statin therapy. Human Genetics, 129(1), pp. 17-23. (doi: 10.1007/s00439-010-0892-6)
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Abstract
A single nucleotide polymorphism (SNP) in <i>KIF6</i>, a member of the <i>KIF9</i> family of kinesins, is associated with differential coronary event reduction from statin therapy in four randomized controlled trials; this SNP (rs20455) is also associated with the risk for coronary heart disease (CHD) in multiple prospective studies. We investigated whether other common SNPs in the <i>KIF6</i> region were associated with event reduction from statin therapy. Of the 170 SNPs in the <i>KIF6</i> region investigated in the Cholesterol and Recurrent Events trial (CARE), 28 were associated with differential event reduction from statin therapy (P interaction < 0.1 in Caucasians, adjusted for age and sex) and were further investigated in the Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction 22 (PROVE IT-TIMI22) and West of Scotland Coronary Prevention Study (WOSCOPS). These analyses revealed that two SNPs (rs9462535 and rs9471077), in addition to rs20455, were associated with event reduction from statin therapy (P interaction < 0.1 in each of the three studies). The relative risk reduction ranged from 37 to 50% (P < 0.01) in carriers of the minor alleles of these SNPs and from −4 to 13% (P > 0.4) in non-carriers. These three SNPs are in high linkage disequilibrium with one another (r 2 > 0.84). Functional studies of these variants may help to understand the role of <i>KIF6</i> in the pathogenesis of CHD and differential response to statin therapy.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Robertson, Mrs Michele and Shepherd, Prof James and Ford, Professor Ian and Packard, Professor Chris |
| Authors: | Li, Y., Sabatine, M.S., Tong, C.H., Ford, I., Kirchgessner, T.G., Packard, C., Robertson, M., Rowland, C.M., Bare, L.A., Shepherd, J., Devlin, J.J., and Iakoubova, O.A. |
| Subjects: | R Medicine > R Medicine (General) |
| College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Human Genetics |
| Publisher: | Springer |
| ISSN: | 0340-6717 |
| ISSN (Online): | 1432-1203 |
| Published Online: | 01 October 2010 |
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