Lamb, G.W., McArdle, P.A., Ramsey, S., McNichol, A.M., Edwards, J. , Aitchison, M. and McMillan, D.C. (2008) The relationship between the local and systemic inflammatory responses and survival in patients undergoing resection for localized renal cancer. BJU International, 102(6), pp. 756-761. (doi: 10.1111/j.1464-410X.2008.07666.x)
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Publisher's URL: http://dx.doi.org/10.1111/j.1464-410X.2008.07666.x
Abstract
To examine the relationship between the systemic inflammatory response (C-reactive protein, CRP), tumour interleukin-6 receptor and cyclooxygenase (COX)-2 expression, tumour T-lymphocytic (CD4+, CD8+) infiltration and cancer survival in patients undergoing resection for renal cell carcinoma (RCC), as both the local and systemic inflammatory responses appear to predict the outcome in these patients. <b>PATIENTS AND METHODS:</b> The study included 60 patients undergoing nephrectomy for localized RCC. Pre-operative circulating CRP levels were measured and tumour interleukin-6 receptor and COX-2 expression, tumour CD4+ and CD8+ T lymphocytes were assessed using immunohistochemical analysis. <b>RESULTS:</b> The median follow-up was 78 months, with 14 patients relapsing from their disease and nine cancer-specific deaths. On univariate and multivariate survival analysis, tumour stage and grade and CRP levels were identified as significant factors associated with relapse-free and cancer-specific survival. There was a significant direct relationship between Fuhrman grade and CD4+ T-lymphocytic infiltrate (P > 0.05). An increase in tumour expression of interleukin-6 receptor was weakly associated with an increase in tumour CD8+ T-lymphocytic infiltration (P = 0.057). An increase in tumour CD4+ T-lymphocytic infiltration was associated with an increase in CD8+ T-lymphocytic infiltration (P > 0.01). <b>CONCLUSIONS:</b> The present results suggest that tumour-based factors such as interleukin-6 receptor and COX-2 expression or T-lymphocytic subset infiltration are subordinate to systemic factors such as CRP level in determining survival in patients with localized RCC.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Aitchison, Mr Michael and McMillan, Professor Donald and Edwards, Professor Joanne |
Authors: | Lamb, G.W., McArdle, P.A., Ramsey, S., McNichol, A.M., Edwards, J., Aitchison, M., and McMillan, D.C. |
Subjects: | R Medicine > RD Surgery R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities |
Journal Name: | BJU International |
Publisher: | Blackwell |
ISSN: | 1464-4096 |
Copyright Holders: | Copyright © 2008 BJU International |
First Published: | First published in BJU International 102(6):756-761 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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