Vitamin antioxidants, lipid peroxidation, tumour stage, the systemic inflammatory response and survivial in patients with colorectal cancer

Leung, E.Y.L. , Crozier, J.E.M., Talwar, D., O'Reilly, D.S.J., McKee, R.F., Horgan, P.G. and McMillan, D.C. (2008) Vitamin antioxidants, lipid peroxidation, tumour stage, the systemic inflammatory response and survivial in patients with colorectal cancer. International Journal of Cancer, 123(10), pp. 2460-2464. (doi:10.1002/ijc.23811) (PMID:18729200)

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Abstract

Both the tumour growth and progression and the systemic inflammatory response have the potential to increase oxidative stress. We therefore examined the relationship between lipid-soluble antioxidant vitamins, lipid peroxidation, the systemic inflammatory response and survival in patients with primary operable (n = 53) and advanced inoperable (n = 53) colorectal cancer. Compared with those patients with primary operable colorectal cancer, patients with unresectable liver disease had significantly lower median concentrations of alpha-tocopherol (p < 0.001), lutein (p < 0.001), lycopene (p < 0.001), alpha-carotene (p < 0.01) and beta-carotene (p < 0.001) and higher malondialdehyde concentrations. An elevated systemic inflammatory response (Glasgow prognostic score, mGPS) was associated with a greater proportion of females (p < 0.05) and more advanced tumour stage (p < 0.05), lower circulating levels of retinol (p < 0.01), lutein (p < 0.01), lycopene (p < 0.01) and alpha- (p < 0.01) and beta-carotene but not MDA (p = 0.633). In the liver metastases group 41 patients died of their cancer and a further 1 patient died of intercurrent disease on follow-up. On univariate survival analysis, mGPS (p < 0.01), retinol (p < 0.001), alpha-tocopherol (p < 0.05) and alpha-carotene (p < 0.05) were associated significantly with cancer-specific survival. On multivariate survival analysis of these significant variables, only mGPS (p < 0.01) and retinol (p < 0.001) were independently associated with cancer-specific survival. The results of the present study showed that the systemic inflammatory response was associated with a reduction of lipid-soluble antioxidant vitamins, whereas advanced tumour stage was associated with increased lipid peroxidation in patients with colorectal cancer. Of the antioxidant vitamins measured, only retinol was independently associated with cancer-specific survival.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Horgan, Professor Paul and Leung, Dr Elaine and McKee, Dr Ruth and O'Reilly, Dr Denis and McMillan, Professor Donald
Authors: Leung, E.Y.L., Crozier, J.E.M., Talwar, D., O'Reilly, D.S.J., McKee, R.F., Horgan, P.G., and McMillan, D.C.
Subjects:R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
Journal Name:International Journal of Cancer
Publisher:Wiley
ISSN:0020-7136
ISSN (Online):1097-0215
Published Online:26 August 2008

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