Biochemical integration of blood redox state in captive zebra finches (Taeniopygia guttata)

Costantini, D., Monaghan, P. and Metcalfe, N. B. (2011) Biochemical integration of blood redox state in captive zebra finches (Taeniopygia guttata). Journal of Experimental Biology, 214(7), pp. 1148-1152. (doi: 10.1242/jeb.053496) (PMID:21389200)

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Integration is a property of biological systems that refers to the extent to which their components are correlated through functional, structural, developmental or evolutionary interdependency. This study examined patterns of functional integration among different molecular components of the blood redox system (both plasma and red blood cells) in zebra finches (Taeniopygia guttata). Our results show a two cluster organization of the six measured variables: one cluster includes glutathione peroxidase in both red blood cells and plasma, thiol concentration in red blood cells and plasma hydroperoxides; the other cluster comprises a measure of the non-enzymatic antioxidant capacity in red blood cells and plasma. The interaction network amongst these variables shows (i) a strong positive connectivity among hydroperoxides, glutathione peroxidase and thiols, and (ii) negative connectivity between non-enzymatic and enzymatic antioxidants. Overall, our results also suggest strong and significant integration between the oxidative state of red blood cells and plasma.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Costantini, Dr David and Monaghan, Professor Pat and Metcalfe, Professor Neil
Authors: Costantini, D., Monaghan, P., and Metcalfe, N. B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Journal of Experimental Biology

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
506221Hormetic effects on oxidative stress response in zebra finchesDavid CostantiniNatural Environment Research Council (NERC)NE/G013888/1RI BIODIVERSITY ANIMAL HEALTH & COMPMED