Are Lipid Ratios Less Susceptible to Change With Systemic Inflammation Than Individual Lipid Components in Patients With Rheumatoid Arthritis?

Toms, T. E., Panoulas, V. F., Douglas, K. M. J., Nightingale, P., Smith, J. P., Griffiths, H., Sattar, N. , Symmons, D. P. M. and Kitas, G. D. (2011) Are Lipid Ratios Less Susceptible to Change With Systemic Inflammation Than Individual Lipid Components in Patients With Rheumatoid Arthritis? Angiology, 62(2), pp. 167-175. (doi:10.1177/0003319710373749)

Full text not currently available from Enlighten.

Publisher's URL: http://dx.doi.org/10.1177/0003319710373749

Abstract

Rheumatoid arthritis (RA) associates with excess cardiovascular risk and there is a need to assess that risk. However, individual lipid levels may be influenced by disease activity and drug use, whereas lipid ratios may be more robust. A cross-sectional cohort of 400 consecutive patients was used to establish factors that influenced individual lipid levels and lipid ratios in RA, using multiple regression models. A further longitudinal cohort of 550 patients with RA was used to confirm these findings, using generalized estimating equations. Cross-sectionally, higher C-reactive protein (CRP) levels correlated with lower levels of total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol ([HDL-C] P <= .015), whereas lipid ratios did not correlate with CRP. The findings were broadly replicated in the longitudinal data. In summary, the effects of inflammation on individual lipid levels may underestimate lipid-associated cardiovascular disease (CVD) risk in RA, thus lipid ratios may be more appropriate for CVD risk stratification in RA.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sattar, Professor Naveed
Authors: Toms, T. E., Panoulas, V. F., Douglas, K. M. J., Nightingale, P., Smith, J. P., Griffiths, H., Sattar, N., Symmons, D. P. M., and Kitas, G. D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Angiology
ISSN:0003-3197

University Staff: Request a correction | Enlighten Editors: Update this record