Spencer, J., Rathnam, R.P., Harvey, A.L., Clements, C.J., Clark, R.L., Barrett, M.P. , Wong, P.E., Male, L., Coles, S.J. and Mackay, S.P. (2011) Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity. Bioorganic and Medicinal Chemistry, 19(5), pp. 1802-1815. (doi: 10.1016/j.bmc.2011.01.010)
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Publisher's URL: http://dx.doi.org/10.1016/j.bmc.2011.01.010
Abstract
A library of 1,4-benzodiazepines has been synthesized and evaluated against Trypanosoma brucei, a causative parasite of Human African trypanosomiasis. Benzodiazepines possessing a P2- transporter motif were found to have MIC values as low as 0.78 mu M.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Barrett, Professor Michael |
Authors: | Spencer, J., Rathnam, R.P., Harvey, A.L., Clements, C.J., Clark, R.L., Barrett, M.P., Wong, P.E., Male, L., Coles, S.J., and Mackay, S.P. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Bioorganic and Medicinal Chemistry |
Journal Abbr.: | Bioorganic Med. Chem. |
ISSN: | 0968-0896 |
Published Online: | 14 January 2011 |
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