Mansfiled, M., Russell, D., Kenny, G., and Kinsella, J. (1997) An investigation of the effect of ondansetron on time to induction of anaesthesia with thiopentone and propofol. European Journal of Anaesthesiology, 14(1). pp. 24-28. (doi:10.1046/j.1365-2346.1997.00080.x)
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In two consecutive, randomized, double-blind studies the effect of ondansetron on the time to induction of anaesthesia with propofol and, subsequently, thiopentone was assessed. In each study 40 patients received either ondansetron 8 mg or placebo immediately before induction of anaesthesia with a standardized dose of propofol (2.5 mg kg(-1)) or thiopentone (5 mg kg(-1)). Times to induction of anaesthesia were determined by assessing loss of verbal response, motor power and eyelash reflex. There was no difference in either study in times to induction of anaesthesia between immediate pre-treatment with ondansetron or placebo. Side effects were minor and of similar incidence in the ondansetron and placebo groups.
|Glasgow Author(s) Enlighten ID:||Kenny, Prof Gavin and Kinsella, Professor John|
|Authors:||Mansfiled, M., Russell, D., Kenny, G., and Kinsella, J.|
|College/School:||College of Medical Veterinary and Life Sciences > School of Medicine|
|Journal Name:||European Journal of Anaesthesiology|
|Publisher:||Lippincott Williams & Wilkins, Ltd.|
|Published Online:||16 August 2006|