Murine models for chronic lymphocytic leukaemia

Michie, A.M. , Nakagawa, R. and McCaig, A.M. (2007) Murine models for chronic lymphocytic leukaemia. Biochemical Society Transactions, 35(5), pp. 1009-1012. (doi: 10.1042/BST0351009)

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Publisher's URL: http://dx.doi.org/10.1042/BST0351009

Abstract

CLL (chronic lymphocytic leukaemia) is characterized by the clonal outgrowth of B-lymphocytes with the distinctive phenotype: CD19<sup>hi</sup>CD5<sup>+</sup>CD23<sup>+</sup>IgM<sup>lo</sup>. These malignant B-cells accumulate in the PB (peripheral blood) and lymphoid organs, and are generally arrested at the G<sub>0</sub>/G<sub>1</sub>-phase of cell cycle and display a resistance to apoptosis. To date, most of the CLL research has been carried out using PB samples obtained from patients with established CLL, which have proved instrumental in characterizing the disease. However, while CLL cells appear to have a defect in apoptosis <i>in vivo</i>, they rapidly undergo apoptosis <i>ex vivo</i>, suggesting that CLL cells are dependent on microenvironmental signals to enhance cell survival. One approach used to define the cellular and molecular events that govern CLL has been the development of murine models that replicate the human disease. As well as providing a deeper understanding of the potential triggers for CLL, these models provide preclinical <i>in vivo</i> systems to test novel therapies. The focus of the present review will be to highlight the recent advances in the development of mouse models for CLL.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Michie, Dr Alison
Authors: Michie, A.M., Nakagawa, R., and McCaig, A.M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Biochemical Society Transactions
Publisher:Portland Press Ltd.
ISSN:0300-5127
ISSN (Online):1470-8752
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
444831Defining the cellular origin of chronic lymphocytic leukaemiaAlison MichieMedical Research Council (MRC)G0601099Institute of Cancer Sciences