Regulation of gene expression by the RNA-binding protein Sam68 in cancer

Rajan, P., Gaughan, L., Dalgliesh, C., El-Sherif, A., Robson, C.N., Leung, H.Y. and Elliott, D.J. (2008) Regulation of gene expression by the RNA-binding protein Sam68 in cancer. Biochemical Society Transactions, 36(3), pp. 505-507. (doi: 10.1042/BST0360505)

Abstract

Sam68 (Src-associated in mitosis 68 kDa) is the prototypical member of the STAR (signal transducer and activator of RNA) family of RNA-binding proteins. Sam68 is implicated in a number of cellular processes including signal transduction, transcription, RNA metabolism, cell cycle regulation and apoptosis. In the present review, we summarize the functions of Sam68 as a transcriptional and post-transcriptional regulator of gene expression, with particular relevance to cancer.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Leung, Professor Hing and Rajan, Dr Prabhakar
• Authors: Rajan, P., Gaughan, L., Dalgliesh, C., El-Sherif, A., Robson, C.N., Leung, H.Y., and Elliott, D.J.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Biochemical Society Transactions
• ISSN: 0300-5127