Mansfield, M.D., James, K., and Kinsella, J. (1996) Influence of dose and timing of administration of morphine on postoperative pain and analgesic requirements. British Journal of Anaesthesia, 76(3), pp. 358-361. (doi:10.1093/bja/76.3.358)
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In a randomized, double-blind study, we have investigated the effect of dose and timing of administration of morphine on postoperative pain and analgesic requirements in 60 patients undergoing hysterectomy, with or without salpingo-oophorectomy. Patients were allocated randomly to one of three groups: during standardized general anaesthesia, group post received morphine 0.15 mg kg(-1) i.v. at peritoneal closure after hysterectomy; group pre-low received morphine 0.15mg kg(-1) on induction of anaesthesia; and group pre-high received morphine 0.3 mg kg(-1) on induction of anaesthesia. Median postoperative morphine consumption (first 24 h) from a PCA system was 68 mg (group post), 56 mg (group pre low) and 43 mg (group pre-high), and total perioperative morphine consumption (induction of anaesthesia to end of 24 h after surgery) was 77 mg (group post), 65 mg (group pre-low) and 63 mg (group pre-high). Pain scores (at rest and on movement) were similar in the three groups. A large dose of morphine 0.3 mg kg-l i.v. on induction of anaesthesia significantly reduced postoperative PCA morphine requirements compared with the smaller dose (0.15 mg kg(-1)) administered at induction or peritoneal closure, in patients undergoing hysterectomy, with or without salpingo-oophorectomy
|Glasgow Author(s) Enlighten ID:||Kinsella, Professor John|
|Authors:||Mansfield, M.D., James, K., and Kinsella, J.|
|College/School:||College of Medical Veterinary and Life Sciences > School of Medicine|
|Journal Name:||British Journal of Anaesthesia|
|Publisher:||Oxford University Press|