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Influence of dose and timing of administration of morphine on postoperative pain and analgesic requirements

Mansfield, M.D., James, K., and Kinsella, J. (1996) Influence of dose and timing of administration of morphine on postoperative pain and analgesic requirements. British Journal of Anaesthesia, 76 (3). pp. 358-361. ISSN 0007-0912 (doi:10.1093/bja/76.3.358)

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Abstract

In a randomized, double-blind study, we have investigated the effect of dose and timing of administration of morphine on postoperative pain and analgesic requirements in 60 patients undergoing hysterectomy, with or without salpingo-oophorectomy. Patients were allocated randomly to one of three groups: during standardized general anaesthesia, group post received morphine 0.15 mg kg(-1) i.v. at peritoneal closure after hysterectomy; group pre-low received morphine 0.15mg kg(-1) on induction of anaesthesia; and group pre-high received morphine 0.3 mg kg(-1) on induction of anaesthesia. Median postoperative morphine consumption (first 24 h) from a PCA system was 68 mg (group post), 56 mg (group pre low) and 43 mg (group pre-high), and total perioperative morphine consumption (induction of anaesthesia to end of 24 h after surgery) was 77 mg (group post), 65 mg (group pre-low) and 63 mg (group pre-high). Pain scores (at rest and on movement) were similar in the three groups. A large dose of morphine 0.3 mg kg-l i.v. on induction of anaesthesia significantly reduced postoperative PCA morphine requirements compared with the smaller dose (0.15 mg kg(-1)) administered at induction or peritoneal closure, in patients undergoing hysterectomy, with or without salpingo-oophorectomy

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s):Kinsella, Prof John
Authors: Mansfield, M.D., James, K., and Kinsella, J.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine
Journal Name:British Journal of Anaesthesia
Publisher:Oxford University Press
ISSN:0007-0912
ISSN (Online):1471-6771

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