Parasite-driven pathogenesis in Trypanosoma brucei infections

Morrison, L.J. (2011) Parasite-driven pathogenesis in Trypanosoma brucei infections. Parasite Immunology, 33(8), pp. 448-455. (doi: 10.1111/j.1365-3024.2011.01286.x)

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Publisher's URL: http://dx.doi.org/10.1111/j.1365-3024.2011.01286.x

Abstract

Summary Trypanosomes are protozoan parasites of medical and veterinary importance. It is well established that different species, sub-species and strains of trypanosome can cause very different disease in the mammalian host, exemplified by the two human-infective subspecies of Trypanosoma brucei that cause either acute or chronic disease. We are beginning to understand how the host response shapes the course of the disease and how genetic variation in the host can be a factor in disease severity, particularly in the mouse model, but until recently the role of parasite genetic variation that determines differential disease outcome has been a neglected area. This review will discuss the recent advances in this field, covering both our current knowledge of the T. brucei genes involved and the approaches that are leading towards the identification of T. brucei virulence genes. Finally, the potential for using parasite genotype variation to examine the evolutionary context of virulence will be discussed

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Morrison, Dr Liam
Authors: Morrison, L.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Parasite Immunology
Publisher:Wiley-Blackwell Publishing Ltd.
ISSN:0141-9838
ISSN (Online):1365-3024

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