Wnt signaling and its role in stem cell-driven intestinal regeneration and hyperplasia

Cordero, J.B. and Sansom, O.J. (2012) Wnt signaling and its role in stem cell-driven intestinal regeneration and hyperplasia. Acta Physiologica, 204(1), pp. 137-143. (doi: 10.1111/j.1748-1716.2011.02288.x)

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Publisher's URL: http://dx.doi.org/10.1111/j.1748-1716.2011.02288.x


Abstract Adult stem cells are crucial for normal tissue homeostasis and regeneration upon damage. Deregulated stem cell proliferation and/or differentiation have been linked to the formation and progression of tumours. Due to its high regenerative potential, the adult intestinal epithelium is an excellent system to study the mechanisms that underpin regeneration and transformation. Since the discovery of stem cell markers in the mammalian intestineGÇö such as Lgr5GÇö and the presence of Drosophila intestinal stem cells there have been field-changing discoveries that have revolutionized our understanding of intestinal homeostasis, stem cells and transformation. We will thus present a brief overview of these advances with an emphasis on the role of canonical Wnt signaling and the lessons learned from genetic tractable model systems

Item Type:Articles
Glasgow Author(s) Enlighten ID:Cordero, Professor Julia and Sansom, Professor Owen
Authors: Cordero, J.B., and Sansom, O.J.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Acta Physiologica
ISSN (Online):1748-1716
Published Online:11 April 2011

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