Effects of short-term treatment with atorvastatin in smokers with asthma - a randomized controlled trial

Braganza, G. et al. (2011) Effects of short-term treatment with atorvastatin in smokers with asthma - a randomized controlled trial. BMC Pulmonary Medicine, 11(16), (doi:10.1186/1471-2466-11-16)

[img] Text
50437.pdf
Available under License Creative Commons Attribution Non-commercial.

520kB

Publisher's URL: http://dx.doi.org/10.1186/1471-2466-11-16

Abstract

<b>Background</b> The immune modulating properties of statins may benefit smokers with asthma. We tested the hypothesis that short-term treatment with atorvastatin improves lung function or indices of asthma control in smokers with asthma.<p></p> <b>Methods</b> Seventy one smokers with mild to moderate asthma were recruited to a randomized double-blind parallel group trial comparing treatment with atorvastatin (40 mg per day) versus placebo for 4 weeks. After 4 weeks treatment inhaled beclometasone (400 ug per day) was added to both treatment arms for a further 4 weeks. The primary outcome was morning peak expiratory flow after 4 weeks treatment. Secondary outcome measures included indices of asthma control and airway inflammation.<p></p> <b>Results</b> At 4 weeks, there was no improvement in the atorvastatin group compared to the placebo group in morning peak expiratory flow [-10.67 L/min, 95% CI -38.70 to 17.37, p=0.449], but there was an improvement with atorvastatin in asthma quality of life score [0.52, 95% CI 0.17 to 0.87 p=0.005]. There was no significant improvement with atorvastatin and inhaled beclometasone compared to inhaled beclometasone alone in outcome measures at 8 weeks.<p></p> <b>Conclusions</b> Short-term treatment with atorvastatin does not alter lung function but may improve asthma quality of life in smokers with mild to moderate asthma. Clinicaltrials.gov identifier: NCT00463827

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Braganza, Dr Georgina and Thomson, Professor Neil and Jolly, Miss Lisa and Weir, Christopher and Lloyd, Miss Suzanne and Mair, Professor Frances and Spears, Dr Mark and Chaudhuri, Dr Rekha and Lafferty, Mrs Jane and Donnelly, Mrs Iona and McSharry, Dr Charles
Authors: Braganza, G., Chaudhuri, R., McSharry, C., Weir, C. J., Donnelly, I., Jolly, L., Lafferty, J., Lloyd, S. M., Spears, M., Mair, F., and Thomson, N. C.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > General Practice and Primary Care
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:BMC Pulmonary Medicine
Publisher:BioMed Central
ISSN:1471-2466
Published Online:07 April 2011
Copyright Holders:Copyright © 2011 The Authors
First Published:First published in BMC Pulmonary Medicine 11(16)
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher
Related URLs:

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
424741Effect of statin on asthma control and airway inflammation in smokers with asthmaNeil ThomsonMedical Research Council (MRC)G0501955Infection Immunity and Inflammation Medicine