Phylogenetic characterisation of naturally occurring feline immunodeficiency virus in the United Kingdom

Samman, A., McMonagle, E.L., Logan, N., Willett, B.J. , Biek, R. and Hosie, M.J. (2011) Phylogenetic characterisation of naturally occurring feline immunodeficiency virus in the United Kingdom. Veterinary Microbiology, 150(3-4), pp. 239-247. (doi:10.1016/j.vetmic.2011.01.027)

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Publisher's URL: http://dx.doi.org/10.1016/j.vetmic.2011.01.027

Abstract

Feline immunodeficiency virus (FIV) is a significant pathogen of domestic and non-domestic felids worldwide. In domestic cats, FIV is classified into five distinct subtypes (A-E) with subtypes A and B distributed most widely. However, little is known about the degree of intrasubtype viral diversity and this may prove critical in determining whether monovalent vaccines are likely to protect against FIV strains within a single subtype. Here, we characterise novel env sequences from 47 FIV strains recovered from infected cats in the United Kingdom and its environs. Phylogenetic analyses revealed that all bar one sequence belonged to subtype A, the predominant subtype in Western Europe. A single sequence was identified as a likely subtype A/C recombinant, intriguing given that subtype C does not appear to exist in either the UK or North Western Europe and suggestive of a recombination event predating its introduction into the UK. Subtype A strains from the UK were not significantly differentiated from representative subtype A isolates found elsewhere suggesting multiple introductions of FIV into the country. Divergence among isolates was comparable to that observed for subtype A isolates worldwide, indicating that FIV in the UK covers the full spectrum of subtype A diversity seen globally. This study demonstrates that while subtype A is predominant in the UK, novel introductions may result in the emergence of novel subtypes or intersubtype recombinants, potentially circumventing vaccine strategies. However, the dominance of subtype A suggests that the development of a regional or subtype-specific protective vaccine for the UK could be achievable

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hosie, Professor Margaret and Willett, Professor Brian and McMonagle, Mrs Elizabeth and Logan, Miss Nicola and Biek, Dr Roman
Authors: Samman, A., McMonagle, E.L., Logan, N., Willett, B.J., Biek, R., and Hosie, M.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Veterinary Microbiology
Publisher:Elsevier BV
ISSN:0378-1135
ISSN (Online):1873-2542
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
363381Rational Design of a Lentiviral VaccineMargaret HosieMedical Research Council (MRC)G0300387Centre for Virus Research