Rodgers, J. , McCabe, C. , Gettinby, G., Bradley, B., Condon, B. and Kennedy, P. G.E. (2011) Magnetic resonance imaging to assess blood-brain barrier damage in murine trypanosomiasis. American Journal of Tropical Medicine and Hygiene, 84(2), pp. 344-350. (doi: 10.4269/ajtmh.2011.10-0487)
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Publisher's URL: http://dx.doi.org/10.4269/ajtmh.2011.10-0487
Abstract
The ability of trypanosomes to invade the brain and induce an inflammatory reaction is well-recognized. This study uses magnetic resonance imaging (MRI) in conjunction with a murine model of central nervous system (CNS) stage trypanosomiasis to investigate this phenomenon at the level of the blood-brain barrier (BBB). Mice were scanned before and after administration of the contrast agent. Signal enhancement maps were generated, and the percentage signal change was calculated. The severity of the neuroinflammation was also assessed. Statistical analysis of the signal change data revealed a significantly (P = 0.028) higher signal enhancement in mice at 28 days post-infection (least squares mean = 26.709) compared with uninfected animals (6.298), indicating the presence of BBB impairment. Leukocytes were found in the meninges and perivascular space of some blood vessels in the infected mice. This study shows that the integrity of the BBB is compromised during CNS stage trypanosomiasis and that the impairment does not correlate with inflammatory cell infiltration.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Condon, Professor Barrie and Kennedy, Professor Peter and Bradley, Mrs Barbara and McCabe, Dr Chris and Rodgers, Dr Jean |
| Authors: | Rodgers, J., McCabe, C., Gettinby, G., Bradley, B., Condon, B., and Kennedy, P. G.E. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
| Journal Name: | American Journal of Tropical Medicine and Hygiene |
| Publisher: | American Society of Tropical Medicine and Hygiene |
| ISSN: | 0002-9637 |
| ISSN (Online): | 1476-1645 |
| Related URLs: |
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