Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials

van de Sande, M. G. H. et al. (2011) Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials. Annals of the Rheumatic Diseases, 70(3), pp. 423-427. (doi:10.1136/ard.2010.139550) (PMID:21109518)

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Abstract

Inflammation of synovium is one of the hallmarks of rheumatoid arthritis (RA). Analysis of synovial tissue has increased our understanding of RA pathogenesis, aided in identifying potential therapeutic targets and has been used in the response and mechanistic evaluation of antirheumatic treatments. In addition, studies are ongoing, aimed at the identification of diagnostic and prognostic biomarkers in the synovium. This paper outlines the currently used procedures for sampling and processing of synovial tissue, and presents a standardised recommendation to support multicentre translational research

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McInnes, Professor Iain
Authors: van de Sande, M. G. H., Gerlag, D. M., Lodde, B. M., van Baarsen, L. G. M., Alivernini, S., Codullo, V., Felea, I., Vieira-Sousa, E., Fearon, U., Reece, R., Montecucco, C., Veale, D. J., Pitzalis, C., Emery, P., Klareskog, L., McInnes, I.B., and Tak, P. P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Annals of the Rheumatic Diseases
ISSN:0003-4967
Published Online:24 November 2010

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