High adiponectin and increased risk of cardiovascular disease and mortality in asymptomatic older men: does NT-proBNP help to explain this association?

Wannamethee, S.G., Welsh, P. , Whincup, P.H., Sawar, N., Thomas, M.C., Gudnarsson, V. and Sattar, N. (2011) High adiponectin and increased risk of cardiovascular disease and mortality in asymptomatic older men: does NT-proBNP help to explain this association? European Journal of Cardiovascular Prevention and Rehabilitation, 18(1), pp. 65-71. (doi:10.1097/HJR.0b013e32833b09d9)

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Publisher's URL: http://dx.doi.org/10.1097/HJR.0b013e32833b09d9

Abstract

Background: Raised adiponectin is associated with increased rather than decreased risk of cardiovascular disease (CVD) and mortality at older age. We examined whether N-terminal pro-brain natriuretic peptide (NT-proBNP), a marker of cardiac dysfunction, may help explain this relationship.

Methods and results: A prospective study of 2879 men aged 60-79 years with no history of CVD at baseline followed-up for a mean of 9 years during which there were 196 major coronary heart disease events (fatal and non-fatal myocardial infarction) and 667 deaths (including 225 CVD deaths), whereas adiponectin concentration was inversely associated with several conventional CVD risk factors; it was significantly and positively associated with NT-proBNP concentration. After adjustment for several vascular risk factors, including renal function and muscle mass, relative risks associated with a top third versus bottom third comparison of adiponectin concentration were 1.51 (1.02-2.23) for coronary heart disease, 1.67 (1.15-2.41) for CVD mortality and 1.41 (1.13-1.95) for all cause mortality. Upon further adjustment for NT-proBNP, these relative risks attenuated to 1.31 (0.88-1.94), 1.31 (0.90-1.91) and 1.26 (1.01-1.59), respectively.

Conclusion: We show for the first time that concomitantly elevated NT-proBNP concentration, at least, partially explains the apparently positive relationship between adiponectin concentration and risk of CVD and mortality in asymptomatic elderly men.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Welsh, Dr Paul and Sattar, Professor Naveed
Authors: Wannamethee, S.G., Welsh, P., Whincup, P.H., Sawar, N., Thomas, M.C., Gudnarsson, V., and Sattar, N.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:European Journal of Cardiovascular Prevention and Rehabilitation
ISSN:1741-8267
ISSN (Online):1741-8275

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