Implications of genome wide association studies for the understanding of type 2 diabetes pathophysiology

Petrie, J. R. , Pearson, E. R. and Sutherland, C. (2011) Implications of genome wide association studies for the understanding of type 2 diabetes pathophysiology. Biochemical Pharmacology, 81(4), pp. 471-477. (doi:10.1016/j.bcp.2010.11.010)

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Publisher's URL: http://dx.doi.org/10.1016/j.bcp.2010.11.010

Abstract

The rapid rise in prevalence of type 2 diabetes mellitus(T2DM)has been driven by changes in environmental factors – primarily increased caloric intake and reduced energy expenditure – resulting in reduced whole body insulin sensitivity(often termed insulin resistance). Insulin resistance has been proposed to be a major driver of progression to T2DM. However, of 38 individual susceptibility loci for T2DM recently identified by genome wide association studies, by far the majority code for proteins involved in b-cell function. In this review, we discuss the possible reasons for the paucity of insulin resistance genes and ask whether the new genetic susceptibility data should focus attention on b-cell targets in the development of therapies for T2DM.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Petrie, Professor John
Authors: Petrie, J. R., Pearson, E. R., and Sutherland, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Biochemical Pharmacology
ISSN:0006-2952
Published Online:25 November 2010

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