Identification of genes involved with tick infestation in Bos taurus and Bos indicus

Kongsuwan, K., Piper, E.K., Bagnall, N.H., Ryan, K., Moolhuijzen, P., Bellgard, M., Lew, A., Jackson, L. and Jonsson, N.N. (2008) Identification of genes involved with tick infestation in Bos taurus and Bos indicus. In: Pinard, M.-H. (ed.) Animal Genomics for Animal Health: Paris, France, 25-27 October 2007. Series: Developments in biologicals (132). Karger: Basel, Switzerland, pp. 77-88. ISBN 9783805586191

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Abstract

Tick resistant cattle could provide a potentially sustainable and environmentally sound method of controlling cattle ticks. Advances in genomics and the availability of the bovine genome sequence open up opportunities to identify useful and selectable genes controlling cattle tick resistance. Using quantitative real-time PCR and theAffymetrix bovine array platform, differences in gene expression of skin biopsies from tick resistant Bos indicus (Brahman) and tick susceptible Bos taurus (Holstein-Friesian) cattle following tick challenge were examined. We identified 138 significant differentially-expressed genes, including several immunologicallhost defence genes, extracellularmatrix proteins, and transcription factors as well as genes involved in lipid metabolism. Three key pathways, represented by genes differentially expressed in resistant Brahmans, were identified; the development of the cell-mediated immune response, structural integrity of the dermis and intracellular Ca2+ levels. Ca2+, which is implicated in host responses to microbial stimuli, may be required for the enhancement or fine-tuning of transcriptional activation of Ca2+ -dependant host defence signalling pathways.

Item Type:Book Sections
Status:Published
Glasgow Author(s) Enlighten ID:Jonsson, Professor Nicholas
Authors: Kongsuwan, K., Piper, E.K., Bagnall, N.H., Ryan, K., Moolhuijzen, P., Bellgard, M., Lew, A., Jackson, L., and Jonsson, N.N.
Subjects:Q Science > QR Microbiology
College/School:College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Publisher:Karger
ISBN:9783805586191

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