Antihypertensive drug class and dyslipidemia: risk association among Chinese patients with uncomplicated hypertension

Wong, M.C.S., Jiang, J.Y., Ali, M.K., Fung, H., Griffiths, S. and Mercer, S.W. (2008) Antihypertensive drug class and dyslipidemia: risk association among Chinese patients with uncomplicated hypertension. Journal of Human Hypertension, 22, pp. 648-651. (doi: 10.1038/jhh.2008.46)

Abstract

Factors associated with dyslipidemia in Chinese patients with uncomplicated hypertension were investigated in 1,139 patients newly prescribed a single antihypertensive drug in the public primary healthcare setting in Hong Kong, where their fasting lipid profiles were measured 4 to 16 weeks after the first prescription. Multivariate logistic regression showed that thiazide users were more likely (OR 3.67, 95% C.I. 1.13, 11.88, p=0.030) to have adverse (> 6.2mmol/l) total cholesterol (TC) compared with drugs acting on the renin angiotensin system (RAS), but the absolute difference in mean TC between thiazide users and all patients was small ( 0.14 mmol/l), while advanced age and male gender were also associated with some aspects of dyslipidemia. Clinicians should be aware of the increased risk of dyslipidemia in these groups, but the mild dyslipidemic profile associated with thiazides should not in itself deter its use as a possible first-line antihypertensive agent among Chinese patients.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Mercer, Professor Stewart
• Authors: Wong, M.C.S., Jiang, J.Y., Ali, M.K., Fung, H., Griffiths, S., and Mercer, S.W.
• Subjects: R Medicine > R Medicine (General); R Medicine > RA Public aspects of medicine
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > General Practice and Primary Care
• Journal Name: Journal of Human Hypertension
• Publisher: Nature
• ISSN: 0950-9240
• Copyright Holders: Copyright © 2008 Nature
• First Published: First published in Journal of Human Hypertension 22:648-651
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher.