SNARE proteins underpin insulin-regulated GLUT4 traffic.

Bryant, N.J. and Gould, G.W. (2011) SNARE proteins underpin insulin-regulated GLUT4 traffic. Traffic, 12(6), pp. 657-664. (doi:10.1111/j.1600-0854.2011.01163.x)

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Publisher's URL: http://dx.doi.org/10.1111/j.1600-0854.2011.01163.x

Abstract

Delivery of the glucose transporter, GLUT4 from an intracellular location to the cell surface in response to insulin represents a specialised form of membrane traffic, known to be impaired in the disease states of insulin-resistance and Type-2 diabetes. Like all membrane trafficking events, this translocation of GLUT4 requires members of the SNARE family of proteins. Here we discuss two SNARE complexes that have been implicated in insulin-regulated GLUT4 traffic: One regulating the final delivery of GLUT4 to the cell surface in response to insulin; the other controlling GLUT4's intracellular trafficking.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gould, Professor Gwyn and Bryant, Dr Nia
Authors: Bryant, N.J., and Gould, G.W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Traffic
ISSN:1398-9219

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