Focal adhesions in osteoneogenesis

Biggs, M.J.P. and Dalby, M.J. (2010) Focal adhesions in osteoneogenesis. Proceedings of the Institution of Mechanical Engineers Part H: Journal of Engineering in Medicine, 224(12), pp. 1441-1453. (doi:10.1243/09544119JEIM775)

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Publisher's URL: http://dx.doi.org/10.1243/09544119JEIM775

Abstract

As materials technology and the field of tissue engineering advance, the role of cellular adhesive mechanisms, in particular, interactions with implantable devices, becomes more relevant in both research and clinical practice. A key tenet of medical device technology is to use the exquisite ability of biological systems to respond to the material surface or chemical stimuli in order to help to develop next-generation biomaterials. The focus of this review is on recent studies and developments concerning focal adhesion formation in osteoneogenesis, with an emphasis on the influence of synthetic constructs on integrin-mediated cellular adhesion and function.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Dalby, Professor Matthew
Authors: Biggs, M.J.P., and Dalby, M.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Proceedings of the Institution of Mechanical Engineers Part H: Journal of Engineering in Medicine
Publisher:Professional Engineering Publishing
ISSN:0954-4119

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