Molecular mechanisms underlying the control of antigenic variation in African trypanosomes

Horn, D. and McCulloch, R. (2010) Molecular mechanisms underlying the control of antigenic variation in African trypanosomes. Current Opinion in Microbiology, 13(6), pp. 700-705. (doi:10.1016/j.mib.2010.08.009)

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Publisher's URL: http://dx.doi.org/10.1016/j.mib.2010.08.009

Abstract

African trypanosomes escape the host adaptive immune response by switching their dense protective coat of Variant Surface Glycoprotein (VSG). Each cell expresses only one VSG gene at a time from a telomeric expression site (ES). The [`]pre-genomic' era saw the identification of the range of pathways involving VSG recombination in the context of mono-telomeric VSG transcription. A prominent feature of the early post-genomic era is the description of the molecular machineries involved in these processes. We describe the factors and sequences recently linked to mutually exclusive transcription and VSG recombination, and how these act in the control of the key virulence mechanism of antigenic variation

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McCulloch, Professor Richard
Authors: Horn, D., and McCulloch, R.
Subjects:Q Science > QR Microbiology
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Current Opinion in Microbiology
Publisher:Elsevier
ISSN:1369-5274
ISSN (Online):1879-0364
Published Online:29 September 2010
Copyright Holders:Copyright © 2010 Elsevier
First Published:First published in Current Opinion in Microbiology 2010 13(6): 700-705
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
401101DNA recombination pathways and antigenic variation in trypanosoma bruceiRichard McCullochMedical Research Council (MRC)G0401553Infection Immunity and Inflammation Life Sciences