The human and canine TERT promoters function equivalently in human and canine cells

Arendt, M. L., Nasir, L. and Morgan, I. M. (2010) The human and canine TERT promoters function equivalently in human and canine cells. Veterinary and Comparative Oncology, 8(4), pp. 310-316. (doi:10.1111/j.1476-5829.2010.00227.x)

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Publisher's URL: http://dx.doi.org/10.1111/j.1476-5829.2010.00227.x

Abstract

Telomerase targeted cancer gene therapy is being exploited for treatment of human cancer. The high incidence and many comparative aspects of human and canine cancer and the compliance and dedication of dog owners to treat cancer makes the canine pet population a good clinical model for investigating and developing new cancer therapeutics. Here, we report that the human telomerase promoter operates in canine cells, suggesting that human telomerase promoter-driven cancer therapy can be used to treat cancer in canines. Therefore, the canine pet population can act as a clinical model for new drug development based on telomerase therapeutics.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Nasir, Professor Lubna and Morgan, Professor Iain
Authors: Arendt, M. L., Nasir, L., and Morgan, I. M.
College/School:College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Veterinary and Comparative Oncology
ISSN:1476-5810

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