Retrospective evaluation of the effect of trilostane on insulin requirement and fructosamine concentration in eight diabetic dogs with hyperadrenocorticism

McLauchlan, G., Knottenbelt, C., Augusto, M., Helm, J., McGrotty, Y. and Ramsey, I. (2010) Retrospective evaluation of the effect of trilostane on insulin requirement and fructosamine concentration in eight diabetic dogs with hyperadrenocorticism. Journal of Small Animal Practice, 51(12), pp. 642-648. (doi:10.1111/j.1748-5827.2010.01005.x)

Full text not currently available from Enlighten.

Publisher's URL: http://dx.doi.org/10.1111/j.1748-5827.2010.01005.x

Abstract

Objectives: To describe the effect of trilostane on insulin requirements and serum fructosamine in dogs with diabetes mellitus (DM) and hyperadrenocorticism (HAC). Methods: Observational retrospective study of eight dogs. Results: Median fructosamine concentration at presentation was 401 μmol/L (range 244 to 554 μmol/L). Median insulin dose at presentation was 1·1 IU/kg/dose (0·4 to 2·1 IU/kg/dose) administered twice daily in five animals and once in three. Four dogs had their insulin dose prospectively reduced at the start of trilostane therapy. The HAC was controlled within 28 days in seven dogs. The remaining case was controlled by 17 weeks. Two dogs died within 40 days of starting trilostane. The median fructosamine concentration was 438 μmol/L (range 325 to 600 μmol/L) after stabilisation of the HAC. One case had a consistent reduction in serum fructosamine concentration over the first four months. The median insulin dose after stabilisation of HAC was 1·5 IU/kg dose (range 0·25 to 3·0 IU/kg/dose). Insulin requirements were reduced in two cases after treatment with trilostane. Four dogs required increased insulin doses. Clinical Significance: Insulin requirements and fructosamine concentrations do not consistently reduce during trilostane treatment for HAC. Prospective studies are required to provide recommendations regarding reductions in insulin doses with trilostane treatment.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McLauchlan, Mr Gerard and Ramsey, Professor Ian and Helm, Miss Jenny and Knottenbelt, Professor Clare
Authors: McLauchlan, G., Knottenbelt, C., Augusto, M., Helm, J., McGrotty, Y., and Ramsey, I.
College/School:College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Journal of Small Animal Practice
Publisher:Wiley-Blackwell Publishing Ltd.
ISSN:0022-4510
ISSN (Online):1748-5827
Published Online:01 January 2010

University Staff: Request a correction | Enlighten Editors: Update this record