A molecular framework for coupling cellular volume and osmotic solute transport control

Honsbein, A., Blatt, M.R. and Grefen, C. (2011) A molecular framework for coupling cellular volume and osmotic solute transport control. Journal of Experimental Botany, 62(7), pp. 2363-2370. (doi:10.1093/jxb/erq386)

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Abstract

Eukaryotic cells expand using vesicle traffic to increase membrane surface area. Expansion in walled eukaryotes is driven by turgor pressure which depends fundamentally on the uptake and accumulation of inorganic ions. Thus, ion uptake and vesicle traffic must be controlled coordinately for growth. How this coordination is achieved is still poorly understood, yet is so elemental to life that resolving the underlying mechanisms will have profound implications for our understanding of cell proliferation, development, and pathogenesis, and will find applications in addressing the mineral and water use by plants in the face of global environmental change. Recent discoveries of interactions between trafficking and ion transport proteins now open the door to an entirely new approach to understanding this coordination. Some of the advances to date in identifying key protein partners in the model plant Arabidopsis and in yeast at membranes vital for cell volume and turgor control are outlined here. Additionally, new evidence is provided of a wider participation among Arabidopsis Kv-like K+ channels in selective interaction with the vesicle-trafficking protein SYP121. These advances suggest some common paradigms that will help guide further exploration of the underlying connection between ion transport and membrane traffic and should transform our understanding of cellular homeostasis in eukaryotes.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Blatt, Professor Michael and Grefen, Dr Christopher and Honsbein, Dr Annegret
Authors: Honsbein, A., Blatt, M.R., and Grefen, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Journal of Experimental Botany
ISSN:0022-0957
Published Online:29 November 2010

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
452562Analysis of membrane traffic in adaptive stress tolerance in plantsMichael BlattBiotechnology and Biological Sciences Research Council (BBSRC)BB/F001630/1Institute of Molecular Cell and Systems Biology
453651Systems analysis of guard cell oscillatory mechanics in stomatal dynamicsMichael BlattBiotechnology and Biological Sciences Research Council (BBSRC)BB/F001673/1Institute of Molecular Cell and Systems Biology