Pol II and its associated epigenetic marks are present at Pol III–transcribed noncoding RNA genes

Barski, A., Chepelev, I., Liko, D., Cuddapah, S., Fleming, A., Birch, J. , Cui, K., White, R.J. and Zhao, K. (2010) Pol II and its associated epigenetic marks are present at Pol III–transcribed noncoding RNA genes. Nature Structural and Molecular Biology, 17(5), pp. 629-634. (doi: 10.1038/nsmb.1806) (PMID:20418881) (PMCID:PMC2917008)

Full text not currently available from Enlighten.

Abstract

Epigenetic control is an important aspect of gene regulation. Despite detailed understanding of protein-coding gene expression, the transcription of noncoding RNA genes by RNA polymerase III (Pol III) is less well characterized. Here we profile the epigenetic features of Pol III target genes throughout the human genome. This reveals that the chromatin landscape of Pol III–transcribed genes resembles that of Pol II templates in many ways, although there are also clear differences. Our analysis also uncovered an entirely unexpected phenomenon: namely, that Pol II is present at the majority of genomic loci that are bound by Pol III.

Item Type:Articles
Additional Information:We thank D.E. Schones for assistance with the Solexa Pipeline analysis and helpful discussions. This work was supported by the Intramural Research Program of the US National Institutes of Health, National Heart, Lung, and Blood Institute (K.Z.) and Cancer Research UK (R.J.W.). A.B. was additionally supported by 1K22HL098691-01 Career Transition Award from the National Heart, Lung, and Blood Institute, US National Institutes of Health.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:White, Prof Robert and Birch, Dr Joanna and Fleming, Dr Alastair and Liko, Dr Dritan
Authors: Barski, A., Chepelev, I., Liko, D., Cuddapah, S., Fleming, A., Birch, J., Cui, K., White, R.J., and Zhao, K.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Nature Structural and Molecular Biology
Publisher:Nature Research
ISSN:1545-9993
ISSN (Online):1545-9985

University Staff: Request a correction | Enlighten Editors: Update this record