Hetero‐Oligomerization of Chemokine Receptors

Appelbe, S. and Milligan, G. (2009) Hetero‐Oligomerization of Chemokine Receptors. In: Chemokines, Part B. Series: Methods in Enzymology., 461. Academic Press, pp. 207-225. ISBN 9780123749079 (doi: 10.1016/S0076-6879(09)05410-X)

Abstract

Although traditionally assumed to be monomeric signaling units, G[hyphen (true graphic)]protein-coupled receptors (GPCRs) have been shown to exist as dimers/oligomers. Many chemokine receptors have been demonstrated to form homo[hyphen (true graphic)]oligomers, and hetero[hyphen (true graphic)]oligomerization between both pairs of chemokine receptors and chemokine receptors and other GPCRs has also been demonstrated. This chapter highlights some of the most common techniques used to investigate chemokine receptor oligomerization

• Item Type: Book Sections
• Status: Published
• Glasgow Author(s) Enlighten ID: Appelbe, Mrs Shirley and Milligan, Professor Graeme
• Authors: Appelbe, S., and Milligan, G.
• College/School: College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
• Publisher: Academic Press
• ISSN: 00766879
• ISBN: 9780123749079

Related URLs

• PubMed

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
24249	1	Quantitative Analysis of the Effects of Receptor and G-Protein Mutations and Polymorphisms on Signal Initiation	Graeme Milligan	Medical Research Council (MRC)	G9811527	Institute of Neuroscience and Psychology
24249	2	Quantitative Analysis of the Effects of Receptor and G-Protein Mutations and Polymorphisms on Signal Initiation	Graeme Milligan	Medical Research Council (MRC)	G9811527	Institute of Neuroscience and Psychology
38978	1	The quaternary structure of G-protein coupled receptors - implications for function drug design. Programme grant support renewal	Graeme Milligan	Medical Research Council (MRC)	G9811527	Institute of Neuroscience and Psychology