Quantitative detection of atropine-delayed gastric emptying in the horse by the 13C-octanoic acid breath test

Sutton, D.G.M., Bahr, A., Preston, T., Cohen, N.D., Love, S. and Roussel, A.J. (2002) Quantitative detection of atropine-delayed gastric emptying in the horse by the 13C-octanoic acid breath test. Equine Veterinary Journal, 34(5), pp. 479-485.

[img]
Preview
Text
465.pdf

13MB

Abstract

The 13C-octanoic acid breath test has been correlated significantly to radioscintigraphy for measurement of gastric emptying indices in healthy horses. The objective of this study was to investigate the validity of the test for measurement of equine delayed gastric emptying, prior to its potential clinical application for this purpose. A model of atropine- induced gastroparesis was used. Gastric emptying rate was measured twice in 8 horses using concurrent radioscintigraphy and/or breath test after treatment i.v. with either atropine (0.035 mg/kg bwt) or saline in randomised order. Analysis of both data sets demonstrated that the atropine treatment had caused a significant delay in gastric emptying rate. Paired breath test data showed an atropine-induced delay in gastric half-emptying time t(1/2)), with no overlap in the 99% Cl range (P<0.001). Significant correlations were found between scintigraphy and 13C-octanoic acid breath test for calculation of both t(1/2) (P<0.01) and lag phase duration (P<0.05) in the atropine-delayed emptying results. The mean (s.d.) bias in breath test t(1/2) when compared with scintigraphy was 1.78 (0.58) h. The results demonstrated that the 13C-octanoic acid breath test was an effective diagnostic modality for the measurement of equine delayed gastric emptying. The technique offers advantages to existing methods for clinical investigation, as it is noninvasive, not radioactive, quantitative and requires minimal equipment or training to perform.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Preston, Professor Thomas and Sutton, Dr David and Love, Professor Sandy
Authors: Sutton, D.G.M., Bahr, A., Preston, T., Cohen, N.D., Love, S., and Roussel, A.J.
Subjects:Q Science > QL Zoology
College/School:College of Science and Engineering > Scottish Universities Environmental Research Centre
College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Equine Veterinary Journal
Publisher:Blackwell Publishing
ISSN:0425-1644
ISSN (Online):2042-3306
Copyright Holders:© 2002 Equine Veterinary Journal Ltd
First Published:First published in Equine Veterinary Journal 34(5):479-485
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

University Staff: Request a correction | Enlighten Editors: Update this record