Solution structure of the leader sequence of the patellamide precursor peptide, PatE1-34

Houssen, W.E., Wright, S.H., Kalverda, A.P., Thompson, G.S., Kelly, S.M. and Jaspars, M. (2010) Solution structure of the leader sequence of the patellamide precursor peptide, PatE1-34. ChemBioChem, 11(13), pp. 1867-1873. (doi: 10.1002/cbic.201000305)

Abstract

The solution structure of the leader sequence of the patellamide precursor peptide was analysed by using CD and determined with NOE-restrained molecular dynamics calculations. This leader sequence is highly conserved in the precursor peptides of some other cyanobactins harbouring heterocycles, and is assumed to play a role in targeting the precursor peptide to the post-translational machinery. The sequence was observed to form an a-helix spanning residues 13-28 with a hydrophobic surface on one side of the helix. This hydrophobic surface is proposed to be the site of the initial binding with modifying enzymes

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Kelly, Dr Sharon
• Authors: Houssen, W.E., Wright, S.H., Kalverda, A.P., Thompson, G.S., Kelly, S.M., and Jaspars, M.
• College/School: College of Medical Veterinary and Life Sciences
• Journal Name: ChemBioChem
• ISSN: 1439-4227