Kane, N. M., Xiao, Q., Baker, A. H., Luo, Z., Xu, Q. and Emanueli, C. (2011) Pluripotent stem cell differentiation into vascular cells: a novel technology with promises for vascular re(generation). Pharmacology and Therapeutics, 129(1), pp. 29-49. (doi: 10.1016/j.pharmthera.2010.10.004)
Full text not currently available from Enlighten.
Publisher's URL: http://dx.doi.org/10.1016/j.pharmthera.2010.10.004
Abstract
Several types of stem and progenitor cells are currently under investigation for their potential to accomplish vascular regeneration. This review focuses on embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). We will discuss the technologies allowing for their derivation, culture expansion and maintenance in a pluripotent status. Moreover, both ESCs and iPSCs can be differentiated in endothelial cells (ECs) and mural cell, including vascular smooth muscle cells (VSMCs). Here, we will describe the involvements of growth factors (vascular endothelial growth factors-VEGFs-, platet-derived growth factors-PDGFs-), Wnt and Notch signal pathways, reactive oxygen species (ROS), histone deacetylases (HDACs), and microRNAs (miRNAs) in vascular cell differentiation from pluripotent stem cells. We will additionally describe the therapeutic potential of stem cells for vascular medicine.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Baker, Professor Andrew and Kane, Dr Nicole |
| Authors: | Kane, N. M., Xiao, Q., Baker, A. H., Luo, Z., Xu, Q., and Emanueli, C. |
| Subjects: | Q Science > Q Science (General) |
| College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Pharmacology and Therapeutics |
| Journal Abbr.: | Pharmacol. Ther. |
| Publisher: | Elsevier |
| ISSN: | 0163-7258 |
| ISSN (Online): | 1879-016X |
| Published Online: | 20 October 2010 |
University Staff: Request a correction | Enlighten Editors: Update this record
Funder and Project Information
Funder and Project Information