Lockington, D., Flowers, T.H., Young, D. and Yorston, D. (2010) Assessing the accuracy of intracameral antibiotic preparation for use in cataract surgery. Journal of Cataract and Refractive Surgery, 36(2), pp. 286-289. (doi: 10.1016/j.jcrs.2009.08.034)
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Abstract
<p>Purpose: To evaluate 2 local dilution protocols to assess the accuracy and variability of intracameral antibiotic dosage in cataract surgery. </p> <p>Setting: Tennent Institute of Ophthalmology, Glasgow, United Kingdom. </p> <p>Methods: Ten ophthalmic operating room nurses from 2 local hospitals participated. Oven-dried analytical grade potassium chloride (KCl) was used as a surrogate for cefuroxime. Solutions intended for intracameral use (1.0 mg in 0.1 mL) were prepared according to the 2 protocols. Twenty samples were obtained for each protocol. Ten analytical chemists also performed both dilutions. Concentrations of KCl in each 0.1 mL sample were analyzed by flame photometry. </p> <p>Results: Thirty samples were obtained for each protocol. The median dose after dilution was 1.17 mg (range 0.62 to 1.77 mg) for protocol 1 and 2.05 mg (range 0.52 to 7.25 mg) for protocol 2. The median was significantly higher for protocol 2 (P < .001). There was also greater variability with protocol 2. </p> <p>Conclusions: This study shows that the mathematical accuracy of a dilution protocol does not ensure dosage accuracy in the clinical scenario. Inadequate mixing in a 1.0 mL syringe was probably responsible for the inaccuracy of protocol 2, indicating that small-volume syringes should not be used for mixing. However, protocol 1 had an acceptable range of variability. Replication of this study could evaluate other protocols and address concerns regarding the accuracy of intracameral antibiotic preparations.</p>
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Flowers, Dr Hugh |
Authors: | Lockington, D., Flowers, T.H., Young, D., and Yorston, D. |
Subjects: | R Medicine > RE Ophthalmology R Medicine > RD Surgery |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Journal of Cataract and Refractive Surgery |
ISSN: | 0886-3350 |
ISSN (Online): | 1873-4502 |
Published Online: | 08 January 2010 |
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