Tel/PDGFRβ inhibits self-renewal and directs myelomonocytic differentiation of ES cells

Dobbin, E., Corrigan, P.M., Walsh, C.P., Welham, M.J., Freeburn, R.W. and Wheadon, H. (2008) Tel/PDGFRβ inhibits self-renewal and directs myelomonocytic differentiation of ES cells. Leukemia Research, 32(10), pp. 1554-1564. (doi:10.1016/j.leukres.2008.02.007)

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Abstract

The leukemic oncogene Tel/PDGFRβ, was inducibly expressed in embryonic stem (ES) cells and the phenotypic and molecular changes occurring during hematopoietic differentiation investigated. Expression of Tel/PDGFRβ resulted in an inability of ES cells to self-renew and caused a significant increase in myelopoiesis with a corresponding decrease in erythropoiesis. Analysis of gene expression patterns indicated a dramatic alteration in the levels of genes associated with self-renewal and differentiation, especially myelomonocytic genes in Tel/PDGFRβ-expressing cells. This study indicates Tel/PDGFRβ drives myelopoiesis by altering expression of genes involved in hematopoiesis and demonstrates the potential of this stem cell system to study oncogene-induced pathogenesis.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Wheadon, Dr Helen
Authors: Dobbin, E., Corrigan, P.M., Walsh, C.P., Welham, M.J., Freeburn, R.W., and Wheadon, H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Leukemia Research
ISSN:01452126
Published Online:19 March 2008

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