The functional relationships underlying a synthetic genetic network

Krause, S.A. and Gray, J.V. (2009) The functional relationships underlying a synthetic genetic network. Communicative and Integrative Biology, 2(1), pp. 4-6. (doi: 10.4161/cib.2.1.7298) (PMID:19704853) (PMCID:PMC2649287)

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Abstract

Here, we focus on synthetic lethal genetic interactions, examples of genetic enhancements, where mutations in two different genes result in lethality but only when present together. We recently identified the synthetic lethal network around the PKC1 gene encoding the essential protein kinase C of yeast. We found that this network is heavily enriched for interactions with genes whose products are closely linked to Pkc1 signaling in vivo. Here, we show that: the PKC1 gene elicits a distinct spectrum of genetic interactions to SLT2, encoding a non-essential component of the very same signaling pathway. We also show that the terminal phenotype underlying the synthetic lethal network around PKC1 is not uniform. Synthetic lethal genetic networks thus appear to be very heterogeneous in nature with important implications for what functional relationships can be discovered from them.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Krause, Dr Sue and Gray, Professor Joseph
Authors: Krause, S.A., and Gray, J.V.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Communicative and Integrative Biology
Publisher:Landes Bioscience
ISSN:1942-0889
Published Online:01 January 2009

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
352641A novel post-genomic approach to identify the functions of an essential protein - yeast protein kinase CJoseph GrayBiotechnology and Biological Sciences Research Council (BBSRC)C20144LS - BIOMOLECULAR SCIENCE